YY1 controls Igj repertoire and B-cell development, and localizes with condensin on the Igj locus
نویسندگان
چکیده
Xuan Pan, Madhusudhan Papasani, Yi Hao, Marco Calamito, Fang Wei, William J Quinn III, Arindam Basu, Junwen Wang, Suchita Hodawadekar, Kristina Zaprazna, Huifei Liu, Yang Shi, David Allman, Michael Cancro and Michael L Atchison* Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, Department of Biochemistry, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China and Department of Pathology, Harvard University, Boston, MA, USA
منابع مشابه
YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus.
Conditional knock-out (KO) of Polycomb Group (PcG) protein YY1 results in pro-B cell arrest and reduced immunoglobulin locus contraction needed for distal variable gene rearrangement. The mechanisms that control these crucial functions are unknown. We deleted the 25 amino-acid YY1 REPO domain necessary for YY1 PcG function, and used this mutant (YY1ΔREPO), to transduce bone marrow from YY1 cond...
متن کاملStage-specific expression of two neighboring Crlz1 and IgJ genes during B cell development is regulated by their chromatin accessibility and histone acetylation.
The IgJ gene is expressed in the plasma cell stage. However, its neighboring charged amino acid-rich leucine zipper 1 (Crlz1) gene, which is mapped 30 kb upstream of the IgJ gene in mice, is shown to be expressed in the pre-B cell stage. These stage-specific expressions of two neighboring genes are found to be regulated by their chromatin accessibility and acetylation. Hypersensitive site 1 on ...
متن کاملFunction of YY1 in Long-Distance DNA Interactions
During B cell development, long-distance DNA interactions are needed for V(D)J somatic rearrangement of the immunoglobulin (Ig) loci to produce functional Ig genes, and for class switch recombination (CSR) needed for antibody maturation. The tissue-specificity and developmental timing of these mechanisms is a subject of active investigation. A small number of factors are implicated in controlli...
متن کاملMicroRNAs Encoded by Bovine Leukemia Virus (BLV) Are Associated with Reduced Expression of B Cell Transcriptional Regulators in Dairy Cattle Naturally Infected with BLV
Bovine leukemia virus (BLV) is estimated to infect over 83% of dairy herds and over 40% of all dairy cows in the United States. While, BLV only causes leukemia in a small proportion of animals, research indicates that BLV+ cattle exhibit reduced milk production and longevity that is distinct from lymphoma development. It is hypothesized that BLV negatively affects production by interfering with...
متن کاملPrognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL
BACKGROUND Survival of adults with B-Acute Lymphoblastic Leukemia requires accurate risk stratification of patients in order to provide the appropriate therapy. Contemporary techniques, using clinical and cytogenetic variables are incomplete for prognosis prediction. METHODS To improve the classification of adult patients diagnosed with B-ALL into prognosis groups, two strategies were examine...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013